Analysis of cellular resistance mechanisms to viral oncolysis.pdf

Analysis of cellular resistance mechanisms to viral oncolysis

Robert Strauss

Vectors based on adenoviruses have been designed as targeted anti-cancer therapeutics that showed promising results in pre-clinical applications. Particularly, efforts have focused on the development of oncolytic vectors that can eliminate cancer cells and replicate in a tumor-selective fashion to amplify the input dose. In clinical trials, these oncolytic adenoviruses have generally been proved safe in patients, but have fallen short of their expected therapeutic value as monotherapies. A number of obstacles that hamper the efficacy of adenoviral vectors have been identified. These include several soluble and cellular blood components, the lack of viral receptors, and the extracellular matrix sequestered by tumor stroma. However, the apparent inability of adenoviruses to spread throughout solid tumors could not be fully explained yet. The work in this book sheds light on obstacles that previously had not been taken into account. It was identified that the epithelial phenotype of ovarian cancer cells represents a barrier for adenovirus infection and virus-mediated oncolysis. Furthermore, major discrepancies between phenotypes of tumors in situ and cultured cells were discovered.

Immunological aspects of YB-1-dependent oncolytic virotherapy

4.89 MB DATEIGRÖSSE
9783838124858 ISBN
Kostenlos PREIS
Analysis of cellular resistance mechanisms to viral oncolysis.pdf

Technik

PC und Mac

Lesen Sie das eBook direkt nach dem Herunterladen über "Jetzt lesen" im Browser, oder mit der kostenlosen Lesesoftware Adobe Digital Editions.

iOS & Android

Für Tablets und Smartphones: Unsere Gratis tolino Lese-App

Andere eBook Reader

Laden Sie das eBook direkt auf dem Reader im Hugendubel.de-Shop herunter oder übertragen Sie es mit der kostenlosen Software Sony READER FOR PC/Mac oder Adobe Digital Editions.

Reader

Öffnen Sie das eBook nach der automatischen Synchronisation auf dem Reader oder übertragen Sie es manuell auf Ihr tolino Gerät mit der kostenlosen Software Adobe Digital Editions.

Aktuelle Bewertungen

avatar
Sofya Voigtuh

08.01.2007 · Reovirus shows considerable potential as an oncolytic agent for Ras-activated tumors and is currently in clinical trials. Here we ask whether such tumor cell lines can acquire resistance to Der Hovawart PDF ePUB KINDLE | FAULLOCH PDF

avatar
Mattio Müllers

Notably, only mesenchymal cells and E/M cells in the process of EMT were susceptible to viral oncolysis. In attempts to overcome the observed resistance, it was found that thus far little explored adenovirus serotypes (Ad3, Ad7, Ad11, and Ad14), which use cellular receptor(s) other than CAR and CD46, have superior oncolytic abilities on polarized epithelial tissue. This study therefore Pharmacological modulation of autophagy …

avatar
Noels Schulzen

It was observed that most isolates can bypass resistance mechanisms of parental cells at high m.o.i., and that there is a correlation between the ability to discriminate between transformed and parental cells, and interferon sensitivity. Most interestingly, an interferon-hypersensitive mutant virus was more dependent on Ras activation than any The molecular basis of viral oncolysis: usurpation …

avatar
Jason Leghmann

The intersection between viral oncolysis, drug …

avatar
Jessica Kolhmann

Oncolysis of the primary tumor significantly abrogated systemic resistance to PD-1-immunotherapy leading to improved elimination of disseminated lung tumors. Bourgeois-Daigneault et al. discovered a way to address the ICB resistance for breast cancer, and Samson et al. discovered a way to address this for brain tumors. In both cases, the